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Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition by Shivam Vora, Ariel Andrew, Ramyashree Prasanna Kumar, Deborah Nazareth, Alexis Bonfim-Melo, Yoon Lim, Xin Yee Ong, Madushan Fernando, Yaowu He, John D. Hooper, Nigel AJ McMillan, Jelena Urosevic, Jon Travers, Jamal Saeh, Sharad Kumar, Mathew JK Jones, Brian Gabrielli
Published 2024-11-01Get full text
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Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells by Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew J. K. Jones, Yaowu He, John D. Hooper, Nigel A. J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Daniela Cimini, Jing Chen, Brian Gabrielli
Published 2025-01-01Get full text
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